Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin
نویسندگان
چکیده
منابع مشابه
α2-Chimaerin regulates a key axon guidance transition during development of the oculomotor projection.
The ocular motor system consists of three nerves which innervate six muscles to control eye movements. In humans, defective development of this system leads to eye movement disorders, such as Duane Retraction Syndrome, which can result from mutations in the α2-chimaerin signaling molecule. We have used the zebrafish to model the role of α2-chimaerin during development of the ocular motor system...
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Duane retraction syndrome (DRS) is the most common form of congenital paralytic strabismus in humans and can result from α2-chimaerin (CHN1) missense mutations. We report a knockin α2-chimaerin mouse (Chn1KI/KI) that models DRS. Whole embryo imaging of Chn1KI/KI mice revealed stalled abducens nerve growth and selective trochlear and first cervical spinal nerve guidance abnormalities. Stalled ab...
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Eye movements in vertebrates are controlled by six extraocular muscles innervated by three of the cranial nerves – the oculomotor, trochlear and abducens. Incorrect development of this wiring network can lead to eye movement disorders, such as the congenital condition Duane retraction syndrome (DRS), which results in squint (strabismus). In DRS patients, the abducens nerve is often absent, and ...
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Eye movements in vertebrates are controlled by six extraocular muscles innervated by three of the cranial nerves – the oculomotor, trochlear and abducens. Incorrect development of this wiring network can lead to eye movement disorders, such as the congenital condition Duane retraction syndrome (DRS), which results in squint (strabismus). In DRS patients, the abducens nerve is often absent, and ...
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Eye movements in vertebrates are controlled by six extraocular muscles innervated by three of the cranial nerves – the oculomotor, trochlear and abducens. Incorrect development of this wiring network can lead to eye movement disorders, such as the congenital condition Duane retraction syndrome (DRS), which results in squint (strabismus). In DRS patients, the abducens nerve is often absent, and ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1116481109